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Semaglutide 24 Mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): A randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial

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The peptide must reach your GLP-1 receptors in its original, intact form to suppress appetite, slow gastric emptying, and enhance insulin sensitivity

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GLP-1 medications address several of these pathways simultaneously, and stopping treatment may allow the underlying PCOS-driven metabolic dysfunction to reassert itself