The science isn't even close
They are also associated with lower risks of heart disease in people with obesity
Sinoatrial node chronotropy direct Gs/cAMP signaling via GLP-1R at the hearts pacemaker, running through the pacemaker cells sarcoplasmic-reticulum calcium clock (phospholamban Ser16 and ryanodine-receptor phosphorylation), not the funny current
Recent studies have shown that GLP-1(936) is particularly effective at low glucose concentrations, with its inhibitory effect being similar to that of GLP-1(7-36)
The current market for GLP-1s approved by the FDA for weight management includes Saxenda, Wegovy, Ozempic, Zepbound and Monjaro
In the context of prolonged systemic administration, NMDA receptor antagonists, such as memantine and MK-801 (also known as dizocilpine), induce anorexia and weight loss in rodents 9,10,11