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in glioblastoma multiforme (GBM) cells, it activates AMPK, thereby inhibiting the downstream mTOR expression, and thus upregulating p53/p21 to block G1 progression (Ishikawa et al., 2008)
Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Active Application number US15/034,806 Other languages English (en) Other versions US20160272677A1 (en Inventor Davide Bianchi Marco Valetti Paola Bazza Current Assignee (The listed assignees may be inaccurate
These data indicate that NPC differentiation is exacerbated under chronic hypobaric hypoxia exposure, and some cells cannot differentiate into mature neurons, which may be a reason for exhaustion of the hippocampal NPC pool
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Delivery Method: Subcutaneous Injection
free-drug occupancy method (albumin Kd 1.86 uM, free fraction 0.29%): Willard JCI Insight 2020
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