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Am J Lifestyle Med 7:395404 Sanyal AJ, Chalasani N, Kowdley KV, McCullough A, Diehl AM, Bass NM, Neuschwander-Tetri BA, Lavine JE, Tonascia J, Unalp A, Van Natta M, Clark J, Brunt EM, Kleiner DE, Hoofnagle JH, Robuck PR, Nash CRN (2010) Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis

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In addition, treatment with tirzepatide increased odds of discontinuation of study drug due to adverse events

While tirzepatide often shows superior results in trials, its not a one-size-fits-all solution

However, findings in a systematic review and meta-analysis of prolonged NSAID use (ranging from one to seven years) indicated NSAIDs accelerate OA progression

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