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However, because their appearance can overlap with more serious lesions, a dermatologist may recommend a biopsy or dermoscopic evaluation if the spot changes shape, grows, or develops irregular borders

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& Hurwitz S., 1978

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Metabolic reprogramming in PDAC The oncogenic mutations in KRAS and other genes in PDAC cells, as well as the acidic and hypoxic microenvironment surrounding these cells, induce striking adaptive changes in the metabolic pathways of PDAC cells