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Oral B12 supplementation may be appropriate in specific circumstances: Dietary deficiency in individuals with normal absorption capacity (typically 50-150 micrograms daily) Patient preference (after discussion of relative efficacy) Maintenance therapy in selected cases Higher oral doses (10002000 micrograms daily) may be used in some cases, as only a small percentage is absorbed through passive diffusion when intrinsic factor-mediated absorption is impaired

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For example, when isolating samples from COVID-19 patients, Moghaddam et al

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Yet, the active treatment limited the decline in natural killer cell count and activity that accompanies digestive cancer progression and reduces patient survival (133)

Namun, beberapa efek samping ringan yang mungkin muncul antara lain: Gangguan pencernaan, seperti kembung, mual, atau diare Reaksi kulit ringan, misalnya ruam atau gatal