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December 23, 2023

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309 Kallidinogenase, another microcirculation enhancer, increases capillary blood flow by generating bradykinin, leading to vasodilation and enhanced tissue perfusion

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However, because this distal site of action that cannot utilize tubuloglomerular feedback to ameliorate glomerular hyperfiltration [95, 96], DPP-4 inhibition does not appear to exert early benefits on renal function in type 2 diabetes