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While these medications can offer powerful benefits, they do not replace the essential roles of a healthy diet and regular exercise
These include anorectic effects driven by previously discussed central modulation of satiety and reward pathways and peripheral activation of vagal afferents, delayed gastric emptying, anti-inflammatory properties, potential impact on energy expenditure and the ability to reduce ghrelin levels, which are inherently elevated in PWS ( 2 to 11.3 kg/m 2 ( 2 in 10/14 cases, and an HbA1c improvement in 19/23 cases, without reported serious side effects ( Semaglutide at a dose of 2.4 mg weekly is the first weekly long-acting GLP-1 RA approved for non-syndromic obesity treatment with a mean weight change of 14.9% in individuals with obesity without diabetes ( Our case series presents the long-term efficacy and safety of semaglutide treatment in patients with PWS without diabetes as well as semaglutide efficacy and safety in PWS previously treated with metabolic surgery
We included high-quality, peer-reviewed literature over the last 20 years (20042024), including cohort studies, randomized controlled trials, systematic reviews, meta-analyses, and original research publications
Scientific References Eating disorders: recognition and treatment (NG69)
This promotes reduced contraction and increased relaxation of many parts of the gastric system, including the antrum of the stomach
Although rare, pancreatitis is a serious condition that requires immediate medical attention, with symptoms including severe abdominal pain that may radiate to the back, nausea, and vomiting
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