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Trends Pharmacol Sci 27:63945, PMID: 17056127 Andreyev AY, Kushnareva YE, Starkov AA (2005) Mitochondrial metabolism of reactive oxygen species
This result is the loss of body heat
[] Overproduction of ROS caused by exposure to heavy metals begins from cellular metabolism at the mitochondria and eventually reaches all cellular components and tissues which causes oxidative stress which then can result in the apoptosis of cells
Copper complexation is performed by mixing the purified tripeptide with copper(II) salts (chloride, acetate, or sulfate, depending on the protocol) at controlled pH, with the resulting complex purified by chromatography
Protecting skin barrier & healing damage
The immune system produces antibodies against thyroid proteins, such as TPO and thyroglobulin (Tg), leading to thyroid cell damage and eventual hypothyroidism [75]
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