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It is a first-in-class dual agonist that simultaneously activates two distinct receptor pathways: the glucose-dependent insulinotropic polypeptide (GIP) receptor and the glucagon-like peptide-1 (GLP-1) receptor

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doi: 10.1016/j.diabres.2021.109119 2 NauckMAQuastDRWefersJMeierJJ

Importantly, it should be noted that ALOXs is not the indispensable due to the existence of other enzymatic and nonenzymatic mechanisms for lipid peroxidation

The bacterial cells were harvested, resuspended in binding buffer (20 mM sodium phosphate, pH 7.4, containing 500 mM NaCl and 20 mM imidazole), and lysed by treatment as above, followed by sonication

To view a copy of this licence, visit About this article Cite this article Nemkov, T., Isiksacan, Z., William, N