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gradual dose escalation protocols are designed to minimise this

Derbinski J, Schulte A, Kyewski B, Klein L

On each day of the 10-week treatment period, oral administration was performed in the morning after an overnight fast of 10 h (water was allowed until 2 h before dosing) followed by 2-h post-dose fasting where subjects were not allowed to take any other oral concomitant medications

Monthly check-ins for the first 90 days, then every 4 to 6 weeks once you stabilize