Inhibiting NNMT has been proposed as a therapeutic strategy for metabolic disease
As a naturally occurring amino acid consumed in food daily, toxicity concerns are minimal
AOD 9604 is a synthetic peptide fragment derived from human growth hormone, designed to promote fat breakdown without affecting growth or blood sugar levels
Working with a healthcare provider who understands this relationship, you can calculate a personalized B12 approach based on your kidney function: normal function allows standard dosing, mild decrease might call for 75% of standard doses, moderate decrease might need 50% of standard, and severe decrease might require 25% of standard with closer monitoring
This selectivity occurs because AOD-9604 does not bind to growth hormone receptors in muscle tissue and works primarily through beta-3 adrenergic receptors that are predominantly expressed in fat cells
Rather than directly supplying NAD+ precursors (like NMN or NR), it works by blocking an enzyme that consumes nicotinamide, theoretically preserving the substrate pool for endogenous NAD+ production
