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Its also important to remember that GLP-1 drugs like Ozempic work differently for everyone, and some people may experience more severe side effects than others

Spiller, Phillip C

Spiering, Barry A et al

Research on multi-receptor agonists of incretins may further develop the neuroprotective effects of GLP-1 and related drugs

It is plausible that the two siblings may carry different GLP1R genotypes: the sister might harbor the rs6923761 AA variant, which is associated with a higher weight loss rate, while the brother may carry the GG or GA variant that weakens semaglutide efficacy