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doi: 10.1038/s41598-025-01206-9 162 BrierleyDIHoltMKSinghADe AraujoAMcDougleMVergaraMet al

In a 2024 literature review published in the Journal of the American Pharmacists Association that assessed six clinical trials , researchers found that tirzepatide had a greater impact on absorption of oral hormonal contraceptives compared with other GLP-1s

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Subgroup analyses indicated that this risk was particularly elevated in individuals receiving high-dose treatment, in studies of long-acting agents, and in overweight/obese populations