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The mean percentage of body weight loss at 72 weeks was 15.0% at the lowest dose, and 20.9% in the highest dose cohort (compared to 3.1% in placebo) (NCT04184622)

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They register with the FDA and must follow current Good Manufacturing Practices

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Conversely, if your genes indicate robust satiety signaling, a lower dose may be equally effective

Supportive Care: Guidance on managing potential side effects and making sustainable lifestyle choices