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Exogenous pathways rely on the inhibition of system Xc (cystine/glutamate transporter) and the activation of the transferrin and transferrin receptor 1, while the endogenous pathway mainly involves blocking the activation of GPX4 (Xue et al., 2023)
Accordingly, medians and interquartile ranges (IQRs) are reported for descriptive analyses
Researchers commonly investigate this combination in studies involving cytoskeletal organization, actin polymerization, cell migration, cellular signaling, and multi-pathway peptide interactions
For instance, although GPX4 activators and ACSL4 inhibitors show efficacy in vitro , their pharmacokinetic and pharmacodynamic properties within the human brain microenvironment remain to be systematically evaluated (Majernikova et al., 2021)
