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The Effects of Growth Hormone on Adipose Tissue: Old Observations, New Mechanisms

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Effect of continued weekly subcutaneous semaglutide vs placebo on weight loss maintenance in adults with overweight or obesity: The STEP 4 Randomized Clinical Trial

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GLP-1 agonists like semaglutide (Ozempic) act primarily on metabolic and interoceptive systemstargeting hypothalamus, brainstem, and nucleus tractus solitariusbut they also modulate reward circuitry, including the nucleus accumbens and ventral tegmental area

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Cardiovascular outcomes studies in people with T2D and high cardiovascular risk have shown that DPP4i have an overall cardio-neutral profile 32,33,34,35,36,37 , while GLP1-RAs were associated with decreased all-cause mortality and major adverse cardiovascular events (MACE) 38

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