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Hierarchical cluster analysis was performed using Genesis software version 1.8.1 for Windows ( 2 DAVID calculates a modified Fishers exact P -value to demonstrate enrichment

doi: 10.3390/antibiotics13050392 116 PluznickJ

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Semaglutide 24 mg once a week in adults with overweight or obesity with type 2 diabetes (STEP 2)

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Side-by-side comparison v3.0 transparency score NexLife: 94/100 (6 of 6 pillars) Sesame: 65/100 (0 of 6 pillars) Drugs offered NexLife: Compounded semaglutide + tirzepatide Sesame: Semaglutide Pricing model NexLife: Flat $145/mo sema, $186/mo tirz (12-mo plan, dose-independent) Sesame: $25-$150/visit Clinical model NexLife: MD/DO-supervised, synchronous + async Sesame: Marketplace per-visit telehealth Pharmacy NexLife: Named 503A & 503B partners Sesame: Patient's own pharmacy States covered NexLife: Availability varies by state + DC Sesame: Varies Labs included NexLife: Yes included in monthly Sesame: Add-on or not included Coaching NexLife: 1:1 fitness coaching + personalized nutrition included Sesame: Varies by plan Financing NexLife: Klarna and Afterpay accepted Sesame: Standard card payment Regulatory clarity NexLife: Pre-Rx written disclosure that compounded sema/tirz are not FDA-approved Sesame: Varies Where Sesame wins Lowest-cost visit pricing in the market