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Bodys, A

The STEP 1 trial demonstrated a mean body weight reduction of 14.9% at the 2.4mg maintenance dose over 68 weeks, compared to just 2.4% in the placebo group

& Natoli, G

Challenges and future directions Currently, GLP-1RAs have shown potential for mitigating neurodegeneration

Of appreciable note, in contrast to a vast majority of previously employed anti-obesity medications (48, 143)

That absence of evidence is why it puts provider guidance and baseline assessment ahead of any schedule, rather than presenting a rule that would apply to everyone