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GSH and redox control The initiation of necroptosis is sensitive to cellular redox state

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Under unfolded protein stress conditions, GRP78 binds to unfolded or misfolded proteins and subsequently activates downstream ER stress sensors, including IRE1, PERK, and ATF6, to trigger a response to unfolded proteins (Yoboue et al., 2017) , (Wei et al., 2012)

10.1097/j.pain.0000000000000602 [DOI] [PMC free article] [PubMed] [Google Scholar] Emery C