Phase 2 and interim phase 3 clinical trial data demonstrate robust effectiveness of GLP-1 RAs in achieving MASH resolution, with semaglutide showing additional promise for fibrosis improvement in the ongoing ESSENCE trial
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In the brain, SELENOP is primarily expressed in astrocytes, but neurons have also been identified as a source of endogenous SELENOP through the entire brain (Steinbrenner et al., 2006