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Regulatory authorities advise assessing how renal and hepatic impairment affects the pharmacokinetics of new drugs, as this evaluation may indicate the need for dose adjustment in these populations [12,13,14,15]

Dynamic data was first fit into kinetic models with T 1 as an unknown parameter to estimate apparent in vivo T 1 of VitC, which was subsequently incorporated into the kinetic model as a fixed parameter to generate k assuming T 1 is the same across the subjects

For both the control and the rd1 case, the confidence intervals reveal notable level of uncertainty in these parameters