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Another putative cause of vitamin B-12 deficiency is the high-folatelow vitamin B-12 interaction, first suspected as the cause for observed relapse and exacerbation of the neurological symptoms in patients with pernicious anemia who were prescribed high oral doses of folic acid

C.PanS.BossaN.et al (2019a)

10.1021/ja411006a J

Glucose and pyruvate metabolism in severe chronic obstructive pulmonary disease

It also establishes your baseline hypoglycemia risk, which is relevant if you are taking other glucose-lowering agents alongside a GLP-1 medication

For most people, folic acid is effectively converted into methylfolate and successfully supports methylation