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Primary mechanisms studied: VEGFR2 upregulation, Akt-eNOS axis activation, ERK1/2 and FAK-paxillin signaling, NF-kB downregulation, growth hormone receptor upregulation, Egr1 activation [1] [4] [5]

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Cagrilintide Storage & Handling Cagrilintide Storage Reference State Lyophilized (powder) Storage -4F (-20C) freezer Duration Up to 24 months State Lyophilized (short-term) Storage 35.6-46.4F (2-8C) refrigerator Duration Acceptable for shipping or short storage State Reconstituted (liquid) Storage 35.6-46.4F (2-8C) refrigerator Duration 28-30 days

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Ganoderma lucidum polysaccharide ameliorated diabetes mellitus-induced erectile dysfunction in rats by regulating fibrosis and the NOS/ERK/JNK pathway