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The same trial also notes that the SEMALEAN study (2025): "Patients experienced an average weight loss of 12 kg after 6 months of treatment with Semaglutide", showing significant total-body change along with the internal change

Exenatide treatment ameliorates these morphological alterations and inhibits the mitochondrial apoptotic pathway by suppressing cytochrome c release and favorably modulating the expression of pro-apoptotic (Bax, caspase-3) and anti-apoptotic (Bcl-2) proteins, thereby protecting RGC-5 cells from hyperglycemic injury [43]

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It likely also impacts things like wound healing and memory consolidation