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For example, a better understanding of the pathogenic mechanisms that are specific to each condition, which contribute to the sustained unresolved activation, as well as how fibroblasts interact with surrounding cells, both immune and others

For instance, metformin, is generally well-tolerated but can cause gastrointestinal side effects (e.g., nausea, diarrhea) and, in rare cases, lactic acidosis, particularly in patients with renal impairment [118]