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In individuals with lower baseline muscle mass or body fat reserves, rapid weight loss poses higher risk of sarcopenia, nutritional deficiency, and metabolic derangement

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Specifically, the ability of alcohol to cause a locomotor stimulation, dopamine release in NAc and rCPP, is attenuated after either genetic or pharmacological suppression of the GHSR (58, 73)

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These actions make GLP-1 a promising target in weight management