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Prescription GLP-1 Medications: Mechanism, Cost, and Clinical Evidence GLP-1 receptor agonists (semaglutide, tirzepatide) work by increasing satiety signals in the brain, slowing gastric emptying, and improving insulin secretion

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Our findings confirm that longer diabetes duration is associated with a lower glycaemic response to GLP-1 RAs [3, 6, 16], probably due to declining beta cell function, as intact insulin secretion is necessary for a robust glycaemic response to this drug class [1, 3]

The medicine is a tool, and like any tool, you want to know whether it's actually cutting before you decide to swap it out

If not improved enough, Botox injected into the bladder wall or nerve stimulation (Interstim) can be used in order to relieve symptoms