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Results showed 87.5% of patients experienced pain relief, with benefits sustained at 6-12 month follow-up

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In HG-induced models of human renal cortical epithelial cells (HRCApiC) and human renal proximal tubular epithelial cells (HRPTEpic), metformin restored Parkin protein expression and mitophagy through protein phosphatase (PP2A) activation, and inhibited NF-B activation, thereby reducing apoptosis of human renal epithelial cells under high glucose conditions [142]

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