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In the in vivo experiments, the authors treated the streptozotocin-induced DM mice with exendin-4 at 10 nmol/kg for 4 weeks and found that exendin-4 promoted the peripheral nerve function as reflected by improved current perception threshold and motor and sensory nerve conduction velocity

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This effect was completely abolished by additional treatment with 2 IU depot insulin/day

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Blood-brain barrier integrity parameters shift in experimental systems[10]

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