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doi:10.1093/aje/kwm003
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Lai et al., 2021
Intranasal administration : Employed in studies on hypothalamic IL-2 expression and cognitive outcomes, leveraging the olfactory bulb for CNS entry
Additionally, the peptide's proposed anti-inflammatory properties (via modulation of TNF- and IL-6 in adipose tissue) and potential stimulation of chondrocyte metabolism offered biological plausibility for OA treatment
Besides the action of the GLP-1R agonist (GLP-1RA) on the brainadipocyte axis, there is also recent evidence that its direct action (independent of its CNS actions) in the white adipose tissue induces browning and enhances the lipolytic capacity and mitochondrial biogenesis [8]
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