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While a similar trend was observed between tissue type, with metastatic tissue having decreased immune-cell infiltration when compared to primary tissue, immune cell type enrichment consistently differed between primary and metastatic comparisons and high and low GLP-1R comparisons, suggesting a subgroup-specific pattern of immune modulation
In particular, pro-apoptotic Noxa is dispensable for normal erythropoiesis
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The onset can be in the first 16 weeks of treatment, particularly during the first 28 days [49,51,52]
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