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JPEN J Parenter Enteral Nutr 39(4):401409

Mechanisms of Action: GLP-1 vs Dual GLP-1/GIP Receptor Agonist Semaglutide acts as a GLP-1 receptor agonist

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The use of large GWAS datasets from independent populations enhances the statistical power and robustness of the findings

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The authors never discussed the possibility that PGN complexed with the added proteins to effectively reduce the active concentration of the PGN, or the fact that PGN and CGN are two different molecules, by molecular weight and physiochemical properties, and that those properties could have played a role in the differences observed