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For example, recently it was reported that a rhubarb extract, Rhein, increasing the intestinal population of Bacteroidetes, mediates an increase in ileal GLP-1 producing cells, peripheral GLP-1(7-36) NH2 levels and improved glucose tolerance in diabetic db/db mice (395)

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Both medications delay the gastric emptying of the stomach, reducing hunger, regulating the appetite, and increasing feelings of satiety, making it easier to create a calorie deficit and aid in weight loss

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Berberine's ability to lower fasting glucose and HbA1c stems from its multifaceted actions, including its effect on GLP-1